There is a huge shortage in manpower with the requisite skill sets in protein structure modeling and its application in drug design. This course addresses such a need by imparting a comprehensive training in Protein Modeling and Rational Drug Discovery techniques.

Completed Human Genome Project has revealed the existence of about 40,000 genes. Many of these genes may be used in drug design. There is tremendous potential in using this data to study functional genomics and the corresponding protein structure vis-à-vis drug design.

The objective of this course is to provide job-training in the basic principles of protein structure analysis. You will learn techniques for generating the three dimensional structure of a protein from its amino acid sequence as well as learn about its utilization in structure based drug design studies. The course covers computational approaches to the drug discovery & design processes.

Methodology: Instructor Led Training

Course Contents:

• Explanation of the basic interatomic forces that lead to all Biological structure and function and functiomentals of protein structure, simulation and illustration of protein structure and structure prediction by homology modeling. Overview of Quantitative Structure Activity Relationships (QSAR)

• Introduction to Protein Science

• Structure based Drug Design

• Analog based Drug Design

• Molecular Modeling

• Programming in Java and Perl

• Project Work

Guest lectures will be organized by recognized researchers of the University of Michigan and industry professionals from Pfizer is also form part of the curriculum.